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The Role of Anticoagulation in COVID-19-Induced Hypercoagulability

Juan Simon Rico-Mesa1, Daniel Rosas2, Ashkan Ahmadian-Tehrani2

  • 1Department of Medicine, Division of Internal Medicine, University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229, USA. mesajs@uthscsa.edu.

Current Cardiology Reports
|June 20, 2020
PubMed

Insights

COVID-19 causes hypercoagulability, increasing thrombotic disease risk. Therapeutic anticoagulation shows mortality benefits in high-risk patients, but further research is needed.

Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Hematology

Background:

  • COVID-19 is associated with a high incidence of thrombotic disease, reported up to 31%.
  • Hypercoagulability is a significant factor influencing COVID-19 outcomes.
  • Understanding the hypercoagulable state is crucial for patient management.

Purpose of the Study:

  • To comprehensively analyze hypercoagulability in COVID-19 patients.
  • To describe the infection-related hypercoagulable state.
  • To provide guidance on the potential benefits of anticoagulation based on current literature.

Main Methods:

  • Literature review and analysis of current evidence.
  • Examination of studies reporting thrombotic events in COVID-19.
  • Evaluation of anticoagulation strategies and their outcomes.

Main Results:

  • Therapeutic anticoagulation has demonstrated a significant mortality benefit in high-risk COVID-19 individuals.
  • Scoring systems, like the sepsis-induced coagulopathy score, can aid in risk stratification for anticoagulation.
  • COVID-19-induced hypercoagulability plays a key role in patient prognosis.

Conclusions:

  • Current literature suggests promising evidence for therapeutic anticoagulation in high-risk COVID-19 patients.
  • Risk stratification using scoring systems is supported by evidence.
  • Further research is essential to fully elucidate the risks and benefits of anticoagulation in this population.
Abstract

Keywords:
AnticoagulationCOVID-19HypercoagulabilitySARS-CoV-2

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