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Chemerin concentrations in infants born small for gestational age: correlations with triglycerides and parameters

Asier Léniz1,2,3, Alfredo Fernández-Quintela4,5,6, Marta Del Hoyo3,7

  • 1Nutrition and Obesity Group, Department of Nutrition and Food Science, University of the Basque Country (UPV/EHU) and Lucio Lascaray Research Institute, 01006, Vitoria, Spain.

Journal of Physiology and Biochemistry
|June 20, 2020
PubMed

Insights

Circulating chemerin levels in infants born small for gestational age (SGA) correlate with insulin and triglyceride levels. Early chemerin measurement may predict future metabolic syndrome risk in these children.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Research

Background:

  • Infants born small for gestational age (SGA) face elevated risks for metabolic syndrome later in life.
  • Adipokines, including chemerin, influence growth patterns and metabolic disorder risk in SGA children.
  • Chemerin is implicated in lipid and glucose metabolism, with higher levels observed in obese and diabetic individuals.

Purpose of the Study:

  • To investigate the association between circulating chemerin concentrations and anthropometric/biochemical parameters in SGA children.
  • To determine if early chemerin levels can serve as a predictor for future metabolic alterations in SGA populations.

Main Methods:

  • Prospective, longitudinal study design.
  • Analysis of plasma samples from Caucasian children born SGA.
  • Correlation analysis between chemerin levels and various anthropometric and biochemical parameters (insulin, triglycerides) at 3 and 24 months of age.

Main Results:

  • Significant positive correlations were found between chemerin levels at 3 months and insulin levels at 3 months.
  • Chemerin concentrations at 3 months also showed a positive correlation with triglyceride levels at 24 months.
  • These associations remained significant after adjusting for anthropometric parameters.

Conclusions:

  • Circulating chemerin concentration in early childhood may serve as a potential biomarker for future metabolic alterations in SGA children.
  • Early detection of elevated chemerin could facilitate timely interventions to mitigate metabolic syndrome risks.

Keywords:
ChemerinGlucose homeostasisSGATriglycerides, biochemical parameters

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