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[Behçet's Syndrome]
Theodoros Xenitidis1, Joerg Christoph Henes1
1Abteilung und Lehrstuhl II, Hämatologie/Onkologie/klinische Immunologie/Rheumatologie, Medizinische Universitätsklinik, Universitätsklinikum Tübingen.
Laryngo- Rhino- Otologie
|June 20, 2020
Summary
Behçet
Area of Science:
- Rheumatology and Immunology
- Vascular Medicine
Background:
- Behçet's syndrome (BS) is a complex vasculitis with diverse clinical manifestations.
- Its pathogenesis bridges polygenic autoinflammatory and autoimmune disease characteristics.
- Recent EULAR recommendations (2018) guide management strategies.
Purpose of the Study:
- To provide an overview of Behçet's syndrome classification and pathogenesis.
- To highlight current therapeutic approaches based on affected organs.
- To discuss recent advancements in BS treatment.
Main Methods:
- Review of current literature and clinical guidelines for Behçet's syndrome.
- Analysis of pathogenetic mechanisms.
- Evaluation of therapeutic options including biologics and targeted therapies.
Main Results:
- Behçet's syndrome is a variable vessel vasculitis requiring multidisciplinary care.
- Adalimumab is approved for posterior ocular involvement since 2016.
- Alternative therapies include infliximab, interferon alfa-2a, IL-1 antagonists, and apremilast.
Conclusions:
- Therapeutic decisions in Behçet's syndrome are guided by organ involvement.
- Targeted therapies like adalimumab offer new treatment avenues.
- Ongoing research aims to further elucidate pathogenesis and optimize treatment protocols.
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