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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Hypersensitivities01:30

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
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Related Experiment Video

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Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
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[Behçet's Syndrome].

Theodoros Xenitidis1, Joerg Christoph Henes1

  • 1Abteilung und Lehrstuhl II, Hämatologie/Onkologie/klinische Immunologie/Rheumatologie, Medizinische Universitätsklinik, Universitätsklinikum Tübingen.

Laryngo- Rhino- Otologie
|June 20, 2020
PubMed
Summary

Behçet

Area of Science:

  • Rheumatology and Immunology
  • Vascular Medicine

Background:

  • Behçet's syndrome (BS) is a complex vasculitis with diverse clinical manifestations.
  • Its pathogenesis bridges polygenic autoinflammatory and autoimmune disease characteristics.
  • Recent EULAR recommendations (2018) guide management strategies.

Purpose of the Study:

  • To provide an overview of Behçet's syndrome classification and pathogenesis.
  • To highlight current therapeutic approaches based on affected organs.
  • To discuss recent advancements in BS treatment.

Main Methods:

  • Review of current literature and clinical guidelines for Behçet's syndrome.
  • Analysis of pathogenetic mechanisms.
  • Evaluation of therapeutic options including biologics and targeted therapies.

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Main Results:

  • Behçet's syndrome is a variable vessel vasculitis requiring multidisciplinary care.
  • Adalimumab is approved for posterior ocular involvement since 2016.
  • Alternative therapies include infliximab, interferon alfa-2a, IL-1 antagonists, and apremilast.

Conclusions:

  • Therapeutic decisions in Behçet's syndrome are guided by organ involvement.
  • Targeted therapies like adalimumab offer new treatment avenues.
  • Ongoing research aims to further elucidate pathogenesis and optimize treatment protocols.