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Prognostic factors for surgical margin status and recurrence in partial nephrectomy.
Hüseyin C Demirel1, Sedat Çakmak1, Abdullah H Yavuzsan1
1Department of Urology, Sisli Hamidiye Etfal Training & Research Hospital, Medical Sciences University, Istanbul, Turkey.
International Journal of Clinical Practice
|June 20, 2020
Summary
Surgical indication, not tumor characteristics, impacts positive surgical margins after partial nephrectomy (PN). Tumor size and stage are key predictors of recurrence risk following PN for renal masses.
Area of Science:
- Urology
- Oncology
- Surgical Pathology
Background:
- Partial nephrectomy (PN) is a standard treatment for renal masses.
- Identifying prognostic factors for surgical margin status and recurrence is crucial for patient outcomes.
Purpose of the Study:
- To investigate prognostic factors influencing surgical margin and recurrence rates in patients undergoing PN for renal masses.
- To assess the impact of tumor characteristics and surgical indications on outcomes after PN.
Main Methods:
- Retrospective analysis of 125 patients who underwent open or laparoscopic PN for renal masses.
- Data collected included demographics, clinical findings, operative details, imaging, and follow-up information.
Main Results:
- The positive surgical margin (PSM) rate was 5.6%, and the recurrence rate was 3.2%.
- Tumor size and stage were significantly associated with recurrence (P=.009, P<.001).
- Mandatory surgical indication for PN was linked to a higher PSM rate (P=.025) compared to elective indications.
Conclusions:
- Surgical margin positivity after PN is not significantly associated with tumor characteristics or anatomical scoring systems.
- The indication for PN directly influences PSM rates.
- Tumor size and stage are critical for evaluating recurrence risk post-PN.
