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Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Other Pulmonary Disorders

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.

Fungal Phylum Ascomycota

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Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

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Updated: Dec 18, 2025

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

[Allergic bronchopulmonary aspergillosis].

Fabienne Reinhard-Groebli¹, Jean-Marc Fellrath¹

¹Service de pneumologie, Département de médecine, RHNE site de Pourtalès, 2000 Neuchâtel.

Revue Medicale Suisse

|June 20, 2020

Summary

Allergic bronchopulmonary aspergillosis (ABPA) is an immune response to Aspergillus fumigatus (Af) in asthma or cystic fibrosis patients. Diagnosis requires clinical, radiological, and immunological tests, with steroids as the primary treatment.

Area of Science:

Pulmonology
Immunology
Infectious Diseases

Background:

Allergic bronchopulmonary aspergillosis (ABPA) is a complex immune response to Aspergillus fumigatus (Af) colonization in the bronchi.
It primarily affects patients with asthma or cystic fibrosis, leading to severe lung damage like bronchiectasis and fibrosis.
The exact reasons for developing hypersensitivity and ABPA remain unclear.

Purpose of the Study:

To elucidate the pathogenesis of ABPA.
To highlight the diagnostic challenges and current criteria for ABPA.
To emphasize the established treatment protocols for ABPA.

Main Methods:

Review of clinical, radiological, and immunological diagnostic criteria for ABPA.
Analysis of the immunological response to Aspergillus fumigatus (Af) in affected patients.

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Evaluation of current treatment strategies, focusing on systemic steroids.

Main Results:

ABPA involves recurrent bronchial obstruction, inflammation, and mucoid impaction.
Diagnosis relies on a combination of clinical, radiological, and immunological findings.
Systemic corticosteroids are the primary therapeutic intervention.

Conclusions:

Understanding ABPA pathogenesis requires further research into hypersensitivity development.
Accurate diagnosis necessitates a multidisciplinary approach.
Effective management of ABPA hinges on prompt diagnosis and appropriate steroid therapy.