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Matairesinol ameliorates experimental autoimmune uveitis by suppression of IRBP-specific Th17 cells

Xin Li1, Qiang Gao1, Lei Yang1

  • 1Department of Clinical Laboratory, Tianjin First Centre Hospital, Tianjin, China.

Journal of Neuroimmunology
|June 20, 2020
PubMed

We investigated the effects of matairesinol (MAT) in the experimental autoimmune uveitis (EAU), a classical animal model of uveitis. We found that treatment with MAT could alleviate intraocular inflammation of EAU. Notably, Th17 cells in eyes of EAU mice could be predominantly restrained by MAT. Furthermore, MAT could inhibit Th17 differentiation in vitro. In addition, MAT inhibited the signaling of MAPK and ROR-γt, a pivotal transcription factor for Th17 cell differentiation in vitro and in vivo. Taken together, these results suggested that MAT had immune-suppressive effects on autoimmune inflammation through Th17 cells.

Keywords:
EAUMAPKMatairesinolROR-γtTh17 cells

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