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Technological Approaches for Improving Vaccination Compliance and Coverage.

Céline Lemoine1,2, Aneesh Thakur3, Danina Krajišnik4

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Summary

Novel vaccine delivery technologies, including micro- and nano-technologies, aim to improve immunisation coverage and patient compliance. These innovations focus on alternative administration routes and controlled antigen release for single-dose vaccination strategies.

Keywords:
adjuvantscompliancecutaneous vaccinationmicrofluidicsmucosal vaccinationvaccine delivery

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Area of Science:

  • Vaccinology
  • Biotechnology
  • Nanotechnology

Background:

  • Incomplete immunisation coverage hinders infectious disease control and eradication efforts globally.
  • Vaccines must be safe, effective, and affordable for widespread accessibility.
  • Improving vaccine delivery strategies is crucial to maximize the impact of immunisation programs.

Purpose of the Study:

  • To review the application of micro- and nano-technologies in novel vaccine delivery systems.
  • To explore alternative vaccine administration routes such as mucosal and cutaneous vaccination.
  • To discuss oral vaccine delivery and encapsulation for controlled antigen release and single-dose vaccination.

Main Methods:

  • Review of current literature on micro- and nano-technologies in vaccine delivery.
  • Analysis of alternative administration routes (mucosal, cutaneous, oral).
  • Examination of controlled antigen release mechanisms for single-dose vaccines.

Main Results:

  • Micro- and nano-technologies offer promising avenues for enhancing vaccine delivery.
  • Alternative routes like mucosal and cutaneous vaccination can improve patient compliance and coverage.
  • Encapsulation technologies facilitate controlled antigen release, enabling single-dose vaccination strategies.

Conclusions:

  • Advancements in micro- and nano-technologies are vital for overcoming barriers in vaccine delivery.
  • These technologies have the potential to significantly improve global immunisation coverage and disease prevention.
  • Future research should focus on translating these technologies into practical, cost-effective vaccination solutions.