Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.1K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.1K
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

7.5K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
7.5K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.2K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.2K
Master Transcription Regulators02:23

Master Transcription Regulators

7.6K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.6K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.1K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.1K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

3.7K
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanistic Links Between Obesity and Breast Cancer Progression: Cellular Crosstalk, Metabolic Reprogramming and Microenvironmental Drivers.

Cell biochemistry and function·2026
Same author

The Role of Angiogenesis in Breast Cancer and Obesity: Unravelling the Connection.

International journal of breast cancer·2026
Same author

Exploring the Challenges and Legal Implications of Secondary Use of Health Data in South Africa.

Developing world bioethics·2026
Same author

Protocol: A multi-factorial, multi-centre study, for biomarker identification in healthy controls for comparison to babies with moderate-severe NESHIE.

PloS one·2026
Same author

Autologous Blood Clot Therapy for Wounds: Investigating the Chemotactic Effect on PBMCs and Fibroblasts in Diabetes.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society·2026
Same author

Addressing the limitations of the regulatory landscape in South Africa regarding advanced cell and gene therapies and related sectors involving human cells, tissues and organs.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025

Related Experiment Video

Updated: Dec 18, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.6K

Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways.

Melvin A Ambele1,2, Priyanka Dhanraj1, Rachel Giles1

  • 1Department of Immunology, and SAMRC Extramural Unit for Stem Cell Research and Therapy, Institute for Cellular and Molecular Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria 0001, South Africa.

International Journal of Molecular Sciences
|June 21, 2020
PubMed
Summary

Understanding adipocyte formation (adipogenesis) is crucial for metabolic health. This review explores key molecular players in preadipocyte commitment and differentiation, highlighting gaps in knowledge for therapeutic development.

Keywords:
adipocyte commitmentadipocyte progenitoradipogenesisadipose tissueepigenetic regulatormiRNAsignalling pathwaytranscription factor

More Related Videos

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

2.7K
Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
04:46

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

2.1K

Related Experiment Videos

Last Updated: Dec 18, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
08:34

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

15.6K
Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator
06:08

Author Spotlight: Semi-Automated Isolation of the Stromal Vascular Fraction from Murine White Adipose Tissue Using a Tissue Dissociator

Published on: May 19, 2023

2.7K
Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
04:46

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

2.1K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Metabolic Science

Background:

  • Adipocyte formation (adipogenesis) from multipotent mesenchymal stromal/stem cells is understudied, particularly during embryogenesis.
  • Most research utilizes adult stem/stromal cells, potentially missing embryonic developmental insights.
  • Adipogenesis involves distinct phases: commitment and terminal differentiation.

Purpose of the Study:

  • To review the molecular mechanisms regulating preadipocyte commitment and differentiation.
  • To identify limitations in current understanding of adipogenesis.
  • To explore therapeutic potential for obesity targeting adipose tissue function.

Main Methods:

  • Literature review of signalling pathways, epigenetic modifiers, and transcription factors in adipogenesis.
  • Analysis of studies using embryonic versus adult preadipocytes.
  • Evaluation of clinically relevant molecular players.

Main Results:

  • Limited factors identified for preadipocyte commitment, possibly due to study models.
  • Over a dozen molecular players regulate terminal differentiation, with PPARγ being clinically significant.
  • Significant gaps remain in understanding the complete adipogenesis process.

Conclusions:

  • Further research is needed to elucidate preadipocyte commitment mechanisms.
  • A comprehensive understanding of adipogenesis regulators is essential for developing effective obesity therapeutics.
  • Targeting adipogenesis pathways may offer novel strategies for metabolic disease treatment.