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The Roles of Alternative Splicing in Tumor-immune Cell Interactions

Yue Wang1,2, Honglei Zhang2,3, Baowei Jiao2,4,5

  • 1Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China

Current Cancer Drug Targets
|June 21, 2020
PubMed

Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and protumoral roles in different types of cancer. For example, ULBP1_RI, MLL5Δ21spe, NKp44-1Δ5, MHC-IΔ7, CD200SΔ1, 2, PVR α/β/γ/δ and IL-33 variants 1/2/3 act as regulators in solid tumors and IPAK4-L and, FOXP1ΔN100 exhibit functions in hematological cancers.

Keywords:
Alternative splicingTumor specific-antigens (TSAs)immune systemimmunotherapyneoantigenstumor cells

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