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Spectrum of neuropsychiatric manifestations in COVID-19

Krishna Nalleballe1, Sanjeeva Reddy Onteddu1, Rohan Sharma1

  • 1Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Brain, Behavior, and Immunity
|June 21, 2020
PubMed

Insights

Over 22% of adult COVID-19 patients experienced neuropsychiatric issues, including anxiety, mood disorders, and headaches. Prompt management of these neurological and psychiatric symptoms is crucial for reducing COVID-19 patient morbidity and mortality.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Psychiatry

Background:

  • COVID-19 (Coronavirus Disease 2019) can cause severe complications beyond respiratory issues.
  • Neuroinvasive potential of coronaviruses can lead to neuropsychiatric manifestations.
  • Understanding these manifestations is critical for patient outcomes.

Purpose of the Study:

  • To analyze the prevalence of neuropsychiatric manifestations in adult COVID-19 patients.
  • To identify common neurological and psychiatric symptoms associated with COVID-19.
  • To highlight the importance of early recognition and management of these conditions.

Main Methods:

  • Analysis of adult patients diagnosed with COVID-19.
  • Utilized the TriNetX database, a global health collaborative clinical research network.
  • Data collected from January 20, 2020, to June 10, 2020.

Main Results:

  • Out of 40,469 COVID-19 patients, 9,086 (22.5%) exhibited neuropsychiatric manifestations.
  • Common neurological symptoms included headache (3.7%), sleep disorders (3.4%), and encephalopathy (2.3%).
  • Anxiety disorders (4.6%) and mood disorders (3.8%) were the most frequent psychiatric issues; 0.2% reported suicidal ideation.

Conclusions:

  • COVID-19 is associated with a significant rate of neuropsychiatric manifestations.
  • Neurological and psychiatric symptoms require prompt clinical attention.
  • Early intervention may reduce overall morbidity and mortality in COVID-19 patients.

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