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Headache in children with Sturge-Weber syndrome - Prevalence, associations and impact

L Arkush1, P Prabhakar2, R C Scott3

  • 1Neurosciences Unit, Great Ormond Street Hospital NHS Foundation Trust, UK.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society
|June 21, 2020
PubMed

Insights

Headache is common in children with Sturge-Weber syndrome (SWS), affecting daily life for many. Understanding headache patterns and triggers in SWS is crucial for better patient management.

Area of Science:

  • Neurology
  • Pediatrics
  • Genetics

Background:

  • Sturge-Weber syndrome (SWS) is a rare congenital neurovascular disorder affecting skin, brain, and eyes.
  • Headache is a common symptom in SWS patients, but its characteristics and associations are poorly understood.
  • This study investigates the prevalence, associations, and impact of headaches in pediatric SWS cases.

Purpose of the Study:

  • To determine the prevalence of headaches in children with SWS.
  • To identify clinical associations and symptomology of headaches in this population.
  • To understand the impact of headaches on the daily activities of children with SWS.

Main Methods:

  • Retrospective review of medical records from a national tertiary pediatric SWS clinic.
  • Categorization of patients based on headache history.
  • Multivariable logistic regression analysis to identify independent predictors of headache.

Main Results:

  • 37% of SWS patients reported headaches, often linked to seizures or head trauma.
  • Headaches interfered with daily activities for 25% and occurred frequently ( >1/month) in 39%.
  • Headache was associated with glaucoma and aspirin use; monoplegia/hemiplegia correlated with less frequent headaches.

Conclusions:

  • Headache is a prevalent issue in pediatric SWS, frequently lacking typical migraine features.
  • Headaches significantly impact the daily lives of affected children.
  • Increased awareness of headache characteristics and associations in SWS can enhance clinical management.
Abstract

Keywords:
HeadacheMigraineNeurovascular disorderSturge-weber syndrome

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