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The crosstalk between cellular reprogramming and senescence in aging and regeneration

Aurélie Chiche1, Cheng Chen1, Han Li1

  • 1Cellular Plasticity and Disease Modelling, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France.

Experimental Gerontology
|June 21, 2020
PubMed

Insights

Aging

Area of Science:

  • Gerontology and regenerative medicine.
  • Cellular biology and aging research.

Background:

  • Aging diminishes the body's regenerative capabilities and heightens chronic disease risk.
  • Emerging evidence indicates that the aging process may be reversible.
  • Cellular senescence and reprogramming are key factors influencing aging.

Purpose of the Study:

  • To review the interplay between cellular senescence and reprogramming in aging.
  • To discuss the impact of senescence elimination and cellular reprogramming on aging.
  • To explore combining these strategies for enhanced regeneration and rejuvenation.

Main Methods:

  • Literature review of recent studies on cellular senescence and reprogramming.
  • Analysis of the effects of senescence elimination and reprogramming on aging.
  • Exploration of combined therapeutic strategies.

Main Results:

  • Both senescence elimination and cellular reprogramming demonstrate beneficial effects on tissue regeneration and rejuvenation.
  • These strategies impact the aging process by improving cellular function and tissue repair.
  • Combining senescence elimination and reprogramming shows potential for synergistic effects.

Conclusions:

  • Cellular senescence and reprogramming are critical targets for anti-aging interventions.
  • Reversing aging may be achievable through interventions targeting these cellular processes.
  • Combined approaches hold promise for more effective rejuvenation and enhanced regenerative capacity.
Keywords:
AgingCellular plasticityCellular reprogrammingCellular senescenceRegenerationRejuvenation

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