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The crosstalk between cellular reprogramming and senescence in aging and regeneration
Aurélie Chiche1, Cheng Chen1, Han Li1
1Cellular Plasticity and Disease Modelling, Department of Developmental and Stem Cell Biology, CNRS UMR 3738, Institut Pasteur, 25 Rue du Dr Roux, Paris 75015, France.
Experimental Gerontology
|June 21, 2020
Summary
Aging
Area of Science:
- Gerontology and regenerative medicine.
- Cellular biology and aging research.
Background:
- Aging diminishes the body's regenerative capabilities and heightens chronic disease risk.
- Emerging evidence indicates that the aging process may be reversible.
- Cellular senescence and reprogramming are key factors influencing aging.
Purpose of the Study:
- To review the interplay between cellular senescence and reprogramming in aging.
- To discuss the impact of senescence elimination and cellular reprogramming on aging.
- To explore combining these strategies for enhanced regeneration and rejuvenation.
Main Methods:
- Literature review of recent studies on cellular senescence and reprogramming.
- Analysis of the effects of senescence elimination and reprogramming on aging.
- Exploration of combined therapeutic strategies.
Main Results:
- Both senescence elimination and cellular reprogramming demonstrate beneficial effects on tissue regeneration and rejuvenation.
- These strategies impact the aging process by improving cellular function and tissue repair.
- Combining senescence elimination and reprogramming shows potential for synergistic effects.
Conclusions:
- Cellular senescence and reprogramming are critical targets for anti-aging interventions.
- Reversing aging may be achievable through interventions targeting these cellular processes.
- Combined approaches hold promise for more effective rejuvenation and enhanced regenerative capacity.
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