Emerging role of microRNAs in ischemic stroke with comorbidities

Area of Science:

• Biomedical Science
• Molecular Biology
• Neurology

Background:

• Ischemic stroke is a leading cause of death and disability worldwide.
• Comorbidities significantly worsen stroke outcomes, increasing deficits, mortality, and hospitalization.
• MicroRNAs (miRNAs) are key molecular regulators implicated in ischemic stroke and associated conditions.

Purpose of the Study:

• To review common comorbidities in ischemic stroke: hypertension, diabetes mellitus (DM), and hyperlipidemia.
• To discuss the role of specific miRNAs (miR-126, miR-223, miR-124) in ischemic stroke and comorbidities.
• To provide an overview of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in stroke with comorbidities.

Main Methods:

• Literature review of scientific articles on ischemic stroke, comorbidities, and non-coding RNAs.
• Analysis of the regulatory functions of specific miRNAs in stroke pathogenesis.
• Synthesis of current knowledge on lncRNAs and circRNAs in the context of stroke and comorbidities.

Main Results:

• Hypertension, DM, and hyperlipidemia are prevalent comorbidities that negatively affect stroke prognosis.
• Specific miRNAs, including miR-126, miR-223, and miR-124, play critical roles in modulating ischemic stroke and its associated comorbidities.
• lncRNAs and circRNAs also emerge as significant players in the pathophysiology of stroke with comorbidities.

Conclusions:

• Targeting miRNAs offers a promising therapeutic avenue for treating ischemic stroke and its comorbidities.
• Further research into the roles of lncRNAs and circRNAs may reveal novel therapeutic strategies for stroke management.
• A comprehensive understanding of molecular mediators is essential for improving patient outcomes in ischemic stroke with comorbidities.