Related Experiment Video
Updated: Dec 17, 2025
07:04
Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
932
Promising targets based on pattern recognition receptors for cancer immunotherapy
Ling Bai1, Wenqian Li1, Weijia Zheng2
1Cancer Center, the First Hospital of Jilin University, Changchun, 130021, Jilin, China.
Pharmacological Research
|June 21, 2020
Summary
Pattern recognition receptors (PRRs) are crucial for immune surveillance but can also promote cancer. Research focuses on harnessing PRRs for anti-tumor immunity while managing their dual role in cancer development.
Area of Science:
- Immunology
- Oncology
- Molecular Biology
Background:
- Pattern recognition receptors (PRRs) detect pathogen and damage signals, initiating cellular responses.
- PRRs are integral to immune surveillance and tolerance, forming a defense network within innate and adaptive immunity.
- Dysregulation of PRR signaling contributes to cancer development by influencing the tumor microenvironment.
Purpose of the Study:
- To elucidate the dual role of PRRs in cancer immunity.
- To explore the mechanisms of PRR action in the context of tumor development.
- To review the potential of PRR-based strategies for cancer immunotherapy.
Main Methods:
- Literature review of PRR function in cancer.
- Analysis of signaling cascades triggered by PRR activation.
- Examination of PRR expression in host and tumor cells.
- Assessment of current PRR-targeted immunotherapies.
Main Results:
- PRRs activate anti-tumor immunity but can also foster pro-tumor inflammation.
- PRR signaling influences the tumor microenvironment, impacting cancer progression.
- PRRs are expressed in both host immune cells and tumor cells, highlighting their complex role.
Conclusions:
- Understanding the dual role of PRRs is critical for effective cancer immunotherapy.
- Targeting PRRs offers promising avenues for enhancing anti-cancer immune responses.
- Further research is needed to optimize PRR-based therapies to maximize anti-tumor activity.
More Related Videos
Related Concept Videos
02:57Targeted Cancer Therapies
8.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.5K
01:27Tumor Immunotherapy
1.6K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.6K
01:27Transducer Mechanism: Enzyme-Linked Receptors
3.7K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
3.7K
01:30Cancer Vaccines
867
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
867
02:50Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
02:38Mitogens and the Cell Cycle
7.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.6K