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Prognosis analysis of patients with mental disorders with COVID-19: a single-center retrospective study

Yan Wan1, Juan Wu2, Lihua Ni3

  • 1Psychosis Intensive Care Unit, Affiliated Wuhan Mental Health Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Aging
|June 21, 2020
PubMed

Insights

COVID-19 patients with dementia experienced higher mortality rates compared to those with other mental disorders. Understanding the inflammatory response in dementia patients may help reduce COVID-19 deaths.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Psychiatry

Background:

  • COVID-19 poses significant risks to individuals with pre-existing mental health conditions.
  • Prognosis in mentally disordered patients with COVID-19 requires further investigation.

Purpose of the Study:

  • To identify factors influencing COVID-19 prognosis in patients with mental disorders.
  • To compare mortality rates and clinical parameters between dementia patients and those with other mental disorders.

Main Methods:

  • Retrospective analysis of COVID-19 patients diagnosed in an intensive care unit.
  • Comparison of baseline characteristics, clinical symptoms, and laboratory parameters.
  • Stratification of patients based on mental disorder type and final prognosis (deceased vs. cured).

Main Results:

  • Dementia patients exhibited a significantly higher mortality rate (P = 0.001).
  • Elevated serum levels of White Blood Cell (WBC) count, neutrophil count, and Blood Urea Nitrogen (BUN) were observed in dementia patients.
  • Significant differences in WBC count (p = 0.029), neutrophil count (P = 0.008), and BUN (P = 0.001) between dementia and non-dementia groups.

Conclusions:

  • Dementia is a significant risk factor for increased mortality in COVID-19 patients.
  • The inflammatory response may play a crucial role in the prognosis of dementia patients with COVID-19.
  • Targeting inflammation could be a potential strategy to improve outcomes for this vulnerable population.

Keywords:
COVID-19dementiainflammatory responsemental disorder

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