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Preclinical contraceptive development for men and women
Daniel S Johnston1, Erwin Goldberg2
1Contraception Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Biology of Reproduction
|June 21, 2020
Summary
This research explores preclinical development for non-hormonal contraceptives, focusing on novel target identification and validation. It discusses male reproductive targets expanding options and emerging methods for future contraceptive development.
Area of Science:
- Reproductive biology and pharmacology
- Genomics and bioinformatics in drug discovery
Background:
- Advancements in genomics and bioinformatics are crucial for identifying novel targets in non-hormonal contraceptive research.
- Target validation is essential before significant investment in contraceptive development campaigns.
Purpose of the Study:
- To present research considerations for preclinical non-hormonal contraceptive development.
- To explore innovative strategies for developing a pipeline of contraceptives targeting both male and female reproductive systems.
- To highlight promising product development programs influencing the field.
Main Methods:
- Review of current research in genomics, bioinformatics, and reproductive biology.
- Analysis of target validation strategies for contraceptive development.
- Discussion of emerging non-hormonal contraceptive methods and product development programs.
Main Results:
- Genomics and bioinformatics facilitate novel non-hormonal contraceptive target discovery.
- Male reproductive system targets offer new 'on demand' contraceptive options for women.
- Emerging methods expand contraceptive approaches beyond specific molecular targets.
Conclusions:
- Strategic preclinical development is key for advancing non-hormonal contraceptives.
- A balanced approach considering risk and innovation is needed for pipeline development.
- Innovative research programs are poised to significantly impact future contraceptive options.
Keywords:
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