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Preclinical contraceptive development for men and women

Daniel S Johnston1, Erwin Goldberg2

  • 1Contraception Research Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Biology of Reproduction
|June 21, 2020
PubMed

Insights

This research explores preclinical development for non-hormonal contraceptives, focusing on novel target identification and validation. It discusses male reproductive targets expanding options and emerging methods for future contraceptive development.

Area of Science:

  • Reproductive biology and pharmacology
  • Genomics and bioinformatics in drug discovery

Background:

  • Advancements in genomics and bioinformatics are crucial for identifying novel targets in non-hormonal contraceptive research.
  • Target validation is essential before significant investment in contraceptive development campaigns.

Purpose of the Study:

  • To present research considerations for preclinical non-hormonal contraceptive development.
  • To explore innovative strategies for developing a pipeline of contraceptives targeting both male and female reproductive systems.
  • To highlight promising product development programs influencing the field.

Main Methods:

  • Review of current research in genomics, bioinformatics, and reproductive biology.
  • Analysis of target validation strategies for contraceptive development.
  • Discussion of emerging non-hormonal contraceptive methods and product development programs.

Main Results:

  • Genomics and bioinformatics facilitate novel non-hormonal contraceptive target discovery.
  • Male reproductive system targets offer new 'on demand' contraceptive options for women.
  • Emerging methods expand contraceptive approaches beyond specific molecular targets.

Conclusions:

  • Strategic preclinical development is key for advancing non-hormonal contraceptives.
  • A balanced approach considering risk and innovation is needed for pipeline development.
  • Innovative research programs are poised to significantly impact future contraceptive options.
Keywords:
contraception

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