Related Experiment Video
Updated: Dec 17, 2025
07:05
Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
24.2K
Use of Botulinum Toxin in the Genitourinary System
Michael B Chancellor1, Christopher P Smith2
1Aikens Center for Neurourology Research, Department of Urology, Beaumont Health System and Oakland University William Beaumont School of Medicine, Rochester, MI, USA. Michael.chancellor@beaumont.org.
Handbook of Experimental Pharmacology
|June 21, 2020
Summary
Botulinum toxin injections offer a safe and effective treatment for refractory urinary incontinence in adults. This therapy is approved for neurogenic detrusor overactivity and overactive bladder unresponsive to other medications.
Area of Science:
- Urology
- Urogynecology
- Neurology
Background:
- Botulinum toxin injection is a recognized safe and effective treatment for refractory urinary incontinence within urology and urogynecology.
- Two specific genitourinary indications are approved for botulinum toxin use in adults.
Purpose of the Study:
- To review the application of botulinum toxin for genitourinary indications.
- To focus on bladder injection techniques and explore potential uses in the prostate and pelvic floor.
Main Methods:
- Review of current literature and clinical guidelines regarding botulinum toxin use in genitourinary conditions.
- Discussion of approved indications and dosages for onabotulinumtoxinA (onaBoNTA).
Main Results:
- OnabotulinumtoxinA (onaBoNTA) 200 U is approved for urinary incontinence from detrusor overactivity in neurologic conditions.
- OnabotulinumtoxinA (onaBoNTA) 100 U is approved for overactive bladder symptoms (incontinence, urgency, frequency).
- Both indications are for adult patients with inadequate response or intolerance to anticholinergic medications.
Conclusions:
- Botulinum toxin is a valuable therapeutic option for specific urinary incontinence conditions.
- Further exploration of botulinum toxin's role in prostate and pelvic floor applications is warranted.
Related Concept Videos
01:26Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin
986
Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
The binding of dantrolene to the RYR1...
986
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
895
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
895
01:23Urinary Bladder
2.7K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
2.7K
01:31Skeletal Muscle Relaxants: Therapeutic Uses
799
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
799
01:26Cholinergic Antagonists: Therapeutic Uses
1.2K
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
1.2K
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
1.3K
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
1.3K