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Updated: Dec 17, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
Electrochemical Oxidative Esterification of Thiophenols: Efficient Access to Sulfinic Esters
Chun-Hui Yang1, Cheng Wu1, Jun-Ming Zhang1
1School of Food and Biological Engineering, Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, Hefei University of Technology, Hefei 230009, China.
Background:
The sulfinic esters are important and useful building blocks in organic synthesis.
Objective:
The aim of this study was to develop a simple and efficient method for the synthesis of sulfinic esters.
Materials And Methods:
Constant current electrolysis from thiols and alcohols was selected as the method for the synthesis of sulfinic esters.
Results And Discussion:
A novel electrochemical method for the synthesis of sulfinic esters from thiophenols and alcohols has been developed. Up to 27 examples of sulfinic esters have been synthesized using the current methods. This protocol shows good functional group tolerance as well as high efficiency. In addition, this protocol can be easily scaled up with good efficiency. Notably, heterocycle-containing substrates, including pyridine, thiophene, and benzothiazole, gave the desired products in good yields. A plausible reaction mechanism is proposed.
Conclusion:
This research not only provides a green and efficient method for the synthesis of sulfinic esters but also shows new applications of electrochemistry in organic synthesis. It is considered that this green and efficient synthetic protocol used to prepare sulfinic esters will have good applications in the future.
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Oxidation of Alcohols
The process of oxidation in a chemical reaction is observed in any of the three forms: