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Related Experiment Video

Updated: Dec 17, 2025

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

How to Study Placebo Responses in Motion Sickness with a Rotation Chair Paradigm in Healthy Participants

Published on: December 14, 2014

Placebo effects in pain.

Luana Colloca¹

¹Department of Pain Translational Symptoms Science, School of Nursing, University of Maryland, Baltimore, MD, United States; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD, United States; Departments of Anesthesiology and Psychiatry, School of Medicine, University of Maryland, Baltimore, MD, United States.

International Review of Neurobiology

|June 22, 2020

Summary

This summary is machine-generated.

Placebo effects significantly impact patient outcomes and symptom perception. Understanding these mechanisms in chronic pain can optimize treatments for neurological disorders by managing patient and provider expectations.

Keywords:

Brain imaging Conditioning Expectancy Pain Parkinson's disorder

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Area of Science:

Neuroscience
Psychology
Pain Management

Background:

Placebo effects influence symptom perception and treatment outcomes.
Laboratory settings allow for controlled study of placebo effects, accounting for natural history and patient expectations.
A mechanistic approach has been applied to neurological disorders, including chronic pain.

Purpose of the Study:

To define placebo effects and review their historical context.
To explore the mechanisms underlying placebo effects in chronic pain.
To inform clinical practice for neurological disorders through understanding placebo mechanisms.

Main Methods:

Review of literature on placebo effects.
Focus on mechanistic approaches in laboratory settings.
Analysis of placebo effects in the context of chronic pain and neurological disorders.

Main Results:

Placebo effects are a significant factor in treatment outcomes.
Understanding placebo mechanisms is crucial for neurological disorders.
Patient and provider expectations play a key role.

Conclusions:

Knowledge of placebo mechanisms can guide clinical practice.
Optimizing patient and provider expectations is key for treatment success.
Further research into placebo effects can enhance neurological disorder management.