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Chronic beryllium disease in identical twins.
K McConnochie1, W R Williams, G S Kilpatrick
1Department of Tuberculosis and Chest Diseases, University of Wales College of Medicine, Llandough Hospital, Penarth, South Glamorgan.
British Journal of Diseases of the Chest
|October 1, 1988
Summary
Identical twins developed chronic beryllium disease (CBD) after beryllium exposure. Researchers noted reduced tear secretion in both, a new finding for CBD, suggesting potential genetic links.
Area of Science:
- Occupational Medicine
- Pulmonology
- Genetics
Background:
- Chronic beryllium disease (CBD) is a granulomatous lung disease caused by beryllium exposure.
- Genetic susceptibility is suspected in CBD, similar to sarcoidosis observed in identical twins.
Purpose of the Study:
- To report a case of chronic beryllium disease in identical twins.
- To highlight a novel clinical finding in CBD: reduced tear secretion.
- To explore the role of genetic factors in CBD development.
Main Methods:
- Case study of identical male twins with differing beryllium exposure durations.
- Diagnostic tools included chest radiography, skin biopsy, Schirmer's test for tear secretion, bronchoalveolar lavage, and laser microprobe mass spectrometry (LAMMS).
Main Results:
- Both twins were diagnosed with chronic beryllium disease.
- Twin 1 had a longer beryllium exposure (3+ years) than Twin 2 (21 months).
- Both twins exhibited reduced tear secretion, a previously unreported symptom.
Conclusions:
- Identical twins can develop chronic beryllium disease.
- Reduced tear secretion may be a feature of chronic beryllium disease.
- Genetic predisposition might play a role in the development of chronic beryllium disease.