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Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Published on: July 22, 2013

Genetically-encoded biosensors for analyzing and controlling cellular process in yeast.

Monireh Marsafari¹, Jingbo Ma², Mattheos Koffas³

¹Department of Chemical, Biochemical and Environmental Engineering, University of Maryland, Baltimore County, Baltimore, MD 21250, United States; Department of Agronomy and Plant Breeding, University of Guilan, Rasht, Islamic Republic of Iran.

Current Opinion in Biotechnology

|June 22, 2020

Summary

Yeast synthetic biology utilizes genetically encoded biosensors and actuators for precise control of cellular processes. This review details design principles for advanced sensors to optimize biofuel and pharmaceutical production.

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Temporal Quantification of MAPK Induced Expression in Single Yeast Cells

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells

Published on: October 4, 2013

Area of Science:

Synthetic biology
Biotechnology
Cellular engineering

Background:

Yeast serves as a versatile platform for producing biofuels, chemicals, and pharmaceuticals.
Membrane-bound organelles in yeast enable specialized metabolism and compartmentalization.
Genetic and metabolic event separation allows precise control of gene expression.

Purpose of the Study:

To review advancements in genetically encoded biosensors and actuators for yeast synthetic biology.
To provide an update on the design principles of sensors for precise cellular process control.
To highlight applications in biotechnological production.

Main Methods:

Review of allosteric transcription factors, G protein-coupled receptors (GPCRs), and optogenetics-based sensors.
Analysis of regulatory architecture, protein assembly, and genetic element interactions.
Focus on spatiotemporal control of cellular processes.

Main Results:

Genetically encoded sensors enable in vivo monitoring and control of yeast cellular processes.
Sensor performance (dynamic response, sensitivity, operational range) depends on regulatory elements.
These tools offer precise analysis and control for biotechnological applications.

Conclusions:

Engineered biosensors and actuators are crucial for advancing yeast synthetic biology.
Understanding sensor design principles is key to optimizing cellular functions.
These technologies enhance the precision and efficiency of yeast-based manufacturing.