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Developing neobavaisoflavone nanoemulsion suppresses lung cancer progression by regulating tumor microenvironment
Hui Ye1, Xiaojie He2, Xu Feng3
1Department of Thoracic Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, 030013, China.
Abstract:
It is necessary to create novel, efficacious and harmless therapeutic strategy for lung cancer treatment. The application of nanoemulsion to specifically suppress cancer progression in the tumor microenvironment would be an effective therapy. Neobavaisoflavone (Neo) is an isoflavone isolated from Psoralea corylifolia L, possesses striking anti-inflammatory and anti-cancer effects. In our stduy, Neo significantly reduced reactive oxygen species (ROS) generation in the activated myofibroblast. Furthermore, a novel Neo nanoemulsion (nano-Neo) was prepared to improve Neo solubility and bioavailability. Nano-Neo showed more effectively anti-proliferative role in lung cancer cells. In addition, in vivo analysis further demonstrated that nano-Neo could effectively suppress tumor growth compared to the free Neo-treated mice without noticeable damage to major organs. Furthermore, nano-Neo treatment markedly reduced extracellular matrix (ECM) deposition in tumor samples by repressing transforming growth factor-β (TGF-β)/SMADs signaling pathway. Meanwhile, the activated immune microenvironment in tumor tissues was dramatically improved by nano-Neo through reducing regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) infiltration, as well as improving the count of natural killer (NK) cells and M2 macrophage phenotype switch to pro-inflammatory M1. In addition, we found that the prepared nano-Neo exerted promising tumor targeting efficiency with improved pharmacokinetic properties. Therefore, the novel approach to prepare nano-Neo introduced here might provide an effective strategy for lung cancer treatment with few adverse effects.
Insights
A novel nanoemulsion of Neobavaisoflavone (nano-Neo) effectively targets lung cancer, suppressing tumor growth and improving the immune microenvironment. This promising therapy shows reduced side effects, offering a new strategy for lung cancer treatment.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Lung cancer requires novel, effective, and safe therapeutic strategies.
- Targeting the tumor microenvironment with nanoemulsions offers a promising approach.
- Neobavaisoflavone (Neo), an isoflavone, exhibits anti-inflammatory and anti-cancer properties.
Purpose of the Study:
- To develop and evaluate a novel Neobavaisoflavone nanoemulsion (nano-Neo) for lung cancer treatment.
- To assess nano-Neo's efficacy in suppressing tumor progression and modulating the tumor microenvironment.
- To investigate nano-Neo's pharmacokinetic properties and safety profile.
Main Methods:
- Preparation and characterization of Neobavaisoflavone nanoemulsion (nano-Neo).
- In vitro assessment of nano-Neo's anti-proliferative effects on lung cancer cells.
- In vivo studies in mice to evaluate tumor growth suppression, organ damage, and immune cell modulation.
- Analysis of extracellular matrix deposition and TGF-β/SMADs signaling pathway.
Main Results:
- Nano-Neo demonstrated enhanced anti-proliferative activity against lung cancer cells compared to free Neo.
- In vivo studies showed significant tumor growth suppression by nano-Neo with no noticeable organ damage.
- Nano-Neo reduced extracellular matrix deposition by inhibiting the TGF-β/SMADs pathway.
- Nano-Neo treatment improved the anti-tumor immune microenvironment by modulating regulatory T cells, myeloid-derived suppressor cells, natural killer cells, and M2 macrophages.
- Improved pharmacokinetic properties and tumor targeting efficiency were observed for nano-Neo.
Conclusions:
- The developed nano-Neo formulation is a potentially effective and safe therapeutic strategy for lung cancer.
- Nano-Neo exhibits potent anti-tumor activity by targeting the tumor microenvironment and modulating immune responses.
- This novel nanoemulsion approach holds promise for improving lung cancer treatment outcomes with minimal adverse effects.
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