Related Experiment Video

Updated: Dec 17, 2025

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
05:57

Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

Published on: May 17, 2024

1.1K

Coronavirus SARS-Cov-2 and arterial hypertension - facts and myths

StanisŁaw Surma1, Monika Romańczyk1, Krzysztof Łabuzek2

  • 1Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Poland.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|June 22, 2020
PubMed

Insights

Arterial hypertension is common in COVID-19 deaths. While SARS-CoV-2 uses ACE2, evidence doesn't link hypertension drugs like ACE inhibitors and ARBs to increased infection risk.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Background:

  • Arterial hypertension is a prevalent comorbidity in patients with fatal SARS-CoV-2 infections.
  • Observational studies suggest a link between hypertension, its treatments, and SARS-CoV-2 infection.
  • SARS-CoV-2 entry into cells involves the ACE2 enzyme, but other entry factors are unknown.

Purpose of the Study:

  • To review key information regarding arterial hypertension and COVID-19.
  • To examine the relationship between hypertension treatments and SARS-CoV-2 risk.
  • To discuss potential therapeutic roles of ACE2 in COVID-19.

Main Methods:

  • Literature review of observational and experimental studies.
  • Analysis of existing evidence on SARS-CoV-2 and the renin-angiotensin system.
  • Synthesis of data on comorbidities and viral infection.

Main Results:

  • No clear evidence links ACE inhibitors (ACE) or angiotensin receptor blockers (ARB) to increased SARS-CoV-2 risk.
  • Recombinant ACE2 may offer therapeutic benefits by blocking viral entry.
  • Monitoring blood glucose and lipid profiles is crucial during SARS-CoV-2 infection.

Conclusions:

  • The relationship between arterial hypertension and COVID-19 requires careful consideration.
  • Current evidence does not support increased SARS-CoV-2 risk with ACE or ARB use.
  • Further research is needed to clarify the role of ACE2 and other factors in SARS-CoV-2 pathogenesis.

Keywords:
COVID-19SARS-Cov-2arterial hypertension

More Related Videos

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

5.4K
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-208:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.2K

Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
595
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
520
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
553
Factors affecting Blood pressure01:28

Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
6.2K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
771