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Endocrine abnormalities induced by the antiviral drugs and frequency of their occurrence

Kamil Dyrka1, MiŁosz Miedziaszczyk2, Edyta Szałek3

  • 1Medical University of Poznan, Poland: Student's Scientific Group of Department of Endocrinology, Metabolism and Internal Diseases.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|June 22, 2020
PubMed

Insights

Antiviral drugs can cause adverse effects, including hormonal dysfunctions like diabetes and thyroid issues. Monitoring patients is key to diagnosing and personalizing treatment for these endocrine abnormalities.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Infectious Diseases

Background:

  • Viral infections cause diverse disorders with varying prognoses.
  • New antiviral drugs show promise but can lead to adverse effects (AEs).
  • Hormonal dysfunctions are significant AEs associated with antiviral therapies.

Purpose of the Study:

  • To review endocrine abnormalities induced by antiviral drugs.
  • To discuss the frequency and types of these hormonal dysfunctions.
  • To highlight the importance of monitoring for personalized treatment.

Main Methods:

  • Literature review of articles from the Medline database.
  • Focus on recent publications concerning antiviral therapy and endocrine disorders.
  • Analysis of reported hormonal and metabolic dysfunctions.

Main Results:

  • Antiviral drug treatment is linked to various endocrine AEs.
  • Specific dysfunctions include osteoporosis, thyroid disorders, metabolic syndrome, lipodystrophy, and hyperglycemia.
  • The frequency and nature of these complications vary.

Conclusions:

  • Awareness of antiviral-induced endocrine complications is crucial for timely diagnosis.
  • Personalized antiviral therapy requires monitoring patient's general condition and diagnostic parameters.
  • Early detection and management of endocrinopathies improve patient outcomes.
Keywords:
antiviral drugsendocrine disorders

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