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An Ex vivo Culture System to Study Thyroid Development
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[Association between puberty with thyroid morphology and function in women].

Y Y Wang1, Q Xu1, D L Xu2

  • 1Key Laboratory of Public Health Safety, Ministry of Education, Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China.

Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi
|June 23, 2020
PubMed
Summary

Puberty development significantly impacts female thyroid health. As puberty progresses, thyroid volume increases, nodule rates rise, and triiodothyronine (TT3) and free triiodothyronine (FT3) levels decrease, indicating a notable relationship between development stages and thyroid function.

Keywords:
PubertyThyroid hormonesThyroid nodulesThyroid volume

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Area of Science:

  • Endocrinology
  • Reproductive Health
  • Thyroid Research

Background:

  • Puberty involves significant physiological changes, including hormonal shifts that can influence various endocrine organs.
  • The thyroid gland's morphology and function may be affected by the dynamic hormonal environment during female puberty.

Purpose of the Study:

  • To investigate the relationship between different stages of puberty and thyroid gland morphology and function in adolescent girls.
  • To determine how puberty development influences thyroid volume, nodule prevalence, and key thyroid hormone levels.

Main Methods:

  • A multi-stage cluster sampling approach included 491 first-grade girls from four schools.
  • Thyroid B-ultrasound, physical examinations, and biochemical analyses of urine and blood samples were performed.
  • Puberty Development Self-rating Scale (PDS) and regression models were used to assess puberty stages and their effects on thyroid parameters.

Main Results:

  • Thyroid volume, nodule rate, and free thyroxine (FT4) levels were lowest in the prepubertal stage and increased through puberty.
  • Total triiodothyronine (TT3) and free triiodothyronine (FT3) levels were highest in the prepubertal stage and decreased with advancing puberty.
  • Puberty development showed a negative correlation with TT3 and FT3 levels, with lower levels observed in the postpubertal stage compared to the prepubertal stage.

Conclusions:

  • The progression of puberty is significantly associated with changes in thyroid morphology and function in women.
  • Advancing puberty correlates with increased thyroid volume and a higher likelihood of thyroid nodules.
  • Higher stages of puberty are linked to decreased levels of TT3 and FT3, suggesting a modulation of thyroid hormone activity during development.