Related Experiment Video

Updated: Dec 17, 2025

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
11:17

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays

Published on: January 7, 2016

17.0K

Growth hormone therapy in children with partial growth hormone deficiency. Are we treating the right patients?

Barbara Krukowska-Andrzejczyk1, Maria Kalina2, Barbara Kalina-Faska2

  • 1Division of Pediatrics and Neurology of Developmental Age, The Independent Public Clinical Hospital No. 6 of the Medical University of Silesia in Katowice, John Paul II Upper Silesian Child Health Centre, Poland.

Pediatric Endocrinology, Diabetes, and Metabolism
|June 23, 2020
PubMed

Insights

Recombinant human growth hormone (rhGH) therapy did not show significant benefits for children with partial growth hormone deficiency (pGHD) compared to untreated idiopathic short stature (ISS). Further research is needed to establish better criteria for initiating rhGH treatment in these children.

Area of Science:

  • Pediatric Endocrinology
  • Growth Hormone Therapy
  • Short Stature

Background:

  • Diagnosis of growth hormone deficiency (GHD) in children relies on GH stimulation tests, but cut-off values are inconsistent.
  • Indications for recombinant GH (rhGH) therapy are debated, especially for partial GHD (pGHD) with GH levels between 5-10 ng/ml.

Purpose of the Study:

  • To evaluate the effects of rhGH therapy in children with transient pGHD.
  • To compare rhGH-treated pGHD children with a control group of untreated idiopathic short stature (ISS) children.

Main Methods:

  • A study group of 54 children with pGHD received rhGH treatment.
  • A control group of 32 children with ISS, matched for age and sex, did not receive rhGH treatment.

Main Results:

  • Both groups achieved final heights within normal population ranges.
  • While both groups showed height gain, the difference was not statistically significant after excluding children with familial short stature (FSS).

Conclusions:

  • rhGH treatment did not demonstrate clear benefits for children with pGHD compared to untreated ISS.
  • New criteria beyond arbitrary GH concentration levels are necessary for guiding rhGH treatment decisions in pGHD.
Abstract

Keywords:
growth hormone treatmentpartial growth hormone deficiencyshort stature

More Related Videos

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection02:22

Full-Endoscopic Surgery for Hypothalamic Hamartoma Resection

Published on: April 12, 2024

750
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

19.3K

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
22.0K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
698
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
121
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
563
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
2.9K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.4K