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Updated: Dec 17, 2025
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
Mucoepidermoid carcinoma. An update and review of the literature
A Peraza1, R Gómez1, J Beltran2
1Facultad de Odontología, Universidad Cooperativa de Colombia Sede Villavicencio. Cra 22-06 sector el Barzal, Villavicencio Meta, Colombia.
Objective:
Mucoepidermoid Carcinoma (MEC) is the most common malignant salivary gland neoplasm, representing 10 to 15% of all salivary neoplasms. A review of the literature was conducted in order to determine trends in presentation, diagnostic features, treatment, and outcomes.
Methods:
A PubMed, Embase, and Scopus search was carried out. The search process was performed by 2 independent reviewing authors and inclusion criteria included systematic reviews, meta-analyses, case-controls studies, cohort studies, comparative studies, clinical trials, cross-sectional studies, descriptive studies, experimental studies, case reports, case series studies, and human studies evaluating MEC.
Results:
Females were more affected (54.5%) and the average age was 48.8 years. The most common location of MEC was the parotid glands (56.8%) followed by hard palate (18%). The most frequent clinical presentation was mass (65.2%) followed by ulcer (29.4%) with pressure as their main symptom (64.4%). The most frequent histologic presentation was Low grade (46.7%) followed by Intermediate grade (27.3%) and the most used treatment was surgery (76.2%). The average follow up was 138.5months, and recurrence was reported at 8.5%.
Conclusion:
MEC showed a strong predilection for the parotid glands is frequently painful, most frequently presents as a mass and most commonly has a low-grade histologic presentation.
