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Comparative Efficacy of Chinese Herbal Injections for Treating Pediatric Bronchopneumonia: A Bayesian Network
Xiaojiao Duan1,2, Haojia Wang1, Jiarui Wu1
1Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.
Insights
Network meta-analysis shows Xixinnao injection (XXN) plus western medicine (WM) and Yanhuning injection (YHN) plus WM are effective for pediatric bronchopneumonia. Further safety assessments for Chinese herbal injections (CHIs) are recommended.
Area of Science:
- Pediatric Respiratory Medicine
- Integrative Medicine
- Pharmacological Research
Background:
- Pediatric bronchopneumonia is a prevalent respiratory illness in children.
- Chinese herbal injections (CHIs) are frequently utilized for treating pediatric bronchopneumonia.
- The efficacy of CHIs in this context warrants rigorous scientific evaluation.
Purpose of the Study:
- To evaluate the efficacy of Chinese herbal injections (CHIs) combined with western medicine (WM) for treating pediatric bronchopneumonia.
- To compare various CHIs in conjunction with WM through a network meta-analysis (NMA).
Main Methods:
- A systematic search for randomized controlled trials (RCTs) comparing CHIs + WM versus WM alone was conducted.
- Network meta-analysis was performed using WinBUGS 1.4.3 software.
- Data visualization and analysis were facilitated by Stata 13.0 software.
Main Results:
- 168 RCTs involving 21,917 patients were analyzed.
- Xixinnao injection (XXN) + WM demonstrated the highest probability of efficacy across multiple parameters, including clinical response, fever reduction, cough, and lung consolidation.
- Yanhuning injection (YHN) + WM showed potential as the optimal treatment for lung consolidation, asthma resolution, and reduced hospitalization duration.
Conclusions:
- XXN + WM and YHN + WM emerge as promising therapeutic options for pediatric bronchopneumonia.
- The safety profiles of these Chinese herbal injections require careful monitoring and further investigation.
Introduction:
Pediatric bronchopneumonia is one of the common respiratory diseases in pediatrics. Chinese herbal injections (CHIs) are widely used to treat pediatric bronchopneumonia. In this study, we examined the efficacy of CHIs in the treatment of pediatric bronchopneumonia using a network meta-analysis (NMA).
Methods:
Randomized controlled trials (RCTs) of CHIs combined western medicine (WM) versus WM were searched from electronic databases. WinBUGS 1.4.3 and Stata 13.0 were adopted to compute calculations and prepare graphs, respectively.
Results:
168 RCTs with 21917 patients were included. The results revealed that Xixinnao injection (XXN) + WM had the most probability to be the best intervention in the four aspects of rate of clinical efficacy, antipyretic time, cough disappearance time, and lung shadow disappearance time. While as to lung shadow disappearance time, asthma disappearance time, and hospitalization time, Yanhuning injection (YHN) + WM could be the best intervention. The safety of CHIs needs to be further assessed.
Conclusions:
Based on this NMA, XXN + WM and YHN + WM were potential optimal therapies in pediatric bronchopneumonia, and their safety should be strictly monitored.
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