Related Experiment Video

Updated: Dec 17, 2025

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.3K

The Research Progress of Vascular Macrophages and Atherosclerosis

Yeqing Tong1, Li Cai2,3, Shiyu Yang3

  • 1Hubei Center for Disease Control and Prevention, 430079, China.

Oxidative Medicine and Cellular Longevity
|June 23, 2020
PubMed
Abstract

Insights

Vascular macrophages are key players in atherosclerosis (AS) development. Understanding their mechanisms offers new therapeutic targets for preventing and treating AS.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Pathogenesis of Atherosclerosis

Background:

  • Atherosclerosis (AS) is a significant cardiovascular disease.
  • The role of vascular macrophages in AS pathogenesis is increasingly recognized.

Purpose of the Study:

  • To systematically review the association between vascular macrophages and AS.
  • To elucidate the mechanisms of macrophage accumulation and function in AS.
  • To identify potential therapeutic targets for AS.

Main Methods:

  • Systematic review of recent research studies.
  • Analysis of macrophage accumulation mechanisms in blood vessel walls.
  • Evaluation of macrophage roles and microenvironmental influences in AS.

Main Results:

  • Vascular macrophages are integral to AS development.
  • Macrophage accumulation and function are influenced by the vascular microenvironment.
  • Understanding these mechanisms provides insight into AS pathogenesis.

Conclusions:

  • Vascular macrophages represent promising targets for AS prevention and treatment.
  • Regulation of host genes may offer a strategy for AS management.
  • This review provides clues for future therapies and novel drug targets for AS.

More Related Videos

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

20.1K
Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

10.0K

Related Concept Videos

Inflammation01:38

Inflammation

Overview
61.0K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
622
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
270