Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Cancer01:30

Skin Cancer

5.6K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.6K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

14.3K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
14.3K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

8.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastrointestinal Cryptococcosis in immunosuppressed patients.

Infectious diseases now·2026
Same author

Longitudinal Treatment Outcomes in Patients With Anaplastic Lymphoma Kinase-Rearranged Non-Small Cell Lung Cancer: Results From a Multinational Registry-Based Study in a Predominantly Western Population.

JCO global oncology·2026
Same author

Multi-modal AI for comprehensive breast cancer prognostication.

Nature communications·2026
Same author

Complementary Medicine in Oncology: A Dual-Perspective Examination of Patient Use and Clinician Attitudes.

Kansas journal of medicine·2026
Same author

When Inflammation Mimics Malignancy: Recognizing VEXAS Syndrome in Oncology Practice.

Kansas journal of medicine·2026
Same author

Vitamins and Cancer Risk: A Comprehensive Review of Epidemiologic and Clinical Evidence.

Kansas journal of medicine·2026

Related Experiment Video

Updated: Dec 17, 2025

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

11.8K

Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type: A Case Report.

Ammar Al-Obaidi1, Nathaniel A Parker1, Khalil Choucair1

  • 1Internal Medicine, University of Kansas School of Medicine, Wichita, USA.

Cureus
|June 23, 2020
PubMed
Summary
This summary is machine-generated.

Primary cutaneous diffuse large B-cell lymphoma, leg type, is a rare and aggressive skin cancer. Effective treatment with ibrutinib was achieved in a patient with relapsed disease.

Keywords:
bruton’s tyrosine kinasediffuse large b-cell lymphomaibrutinibleg typelenalidomidemyd88primary cutaneous b-cell lymphoma

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.5K
Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
06:20

Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor

Published on: January 12, 2024

2.4K

Related Experiment Videos

Last Updated: Dec 17, 2025

Enhancing Tumor Content through Tumor Macrodissection
10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

11.8K
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.5K
Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor
06:20

Author Spotlight: Advancing VRL Diagnosis Using Cell-Free DNA Extraction from Vitreous Humor

Published on: January 12, 2024

2.4K

Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare and aggressive skin cancer.
  • This lymphoma variant presents unique diagnostic and therapeutic challenges due to its rarity and poor prognosis.

Observation:

  • An 84-year-old male presented with new skin lesions on the abdomen and thigh.
  • Histopathology and immunohistochemistry confirmed PCDLBCL-LT.

Findings:

  • The patient experienced multiple relapses and refractory disease.
  • Complete response was achieved with fourth-line ibrutinib therapy.

Implications:

  • Prompt diagnosis and aggressive treatment are vital due to the poor prognosis and high recurrence rates of PCDLBCL-LT.
  • Emerging therapies, including targeted immunotherapies and chemotherapy regimens, offer potential for disease control and relapse prevention.