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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

213
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
213
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

246
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
246
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

168
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
168
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

350
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
350
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

228
 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
228
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

234
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
234

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Peripheral Artery Disease and Stroke.

Concetta Zito1, Roberta Manganaro1, Scipione Carerj1

  • 1Department of Clinical and Experimental Medicine, Cardiology Unit, University of Messina, Azienda Ospedaliera Universitaria "Policlinico G. Martino", Messina, Italy.

Journal of Cardiovascular Echography
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Summary
This summary is machine-generated.

Vascular complications like peripheral artery disease (PAD) and stroke are underrecognized side effects of cancer treatments. Early risk assessment and tailored strategies are crucial for managing these risks in patients undergoing chemotherapy or radiotherapy.

Keywords:
Arterial stiffnessatherosclerosisendothelial dysfunctionstrokethrombosis

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Area of Science:

  • Oncology
  • Cardiology
  • Vascular Medicine

Background:

  • Vascular toxicities, including peripheral artery disease (PAD) and stroke, are underrecognized complications of anticancer treatments.
  • While cardiotoxicities receive attention, the vascular risks associated with chemotherapy and radiotherapy are often overlooked.
  • Emerging cancer therapies carry the potential for novel, yet unidentified, vasotoxicities.

Purpose of the Study:

  • To review the spectrum of vascular toxicities associated with various anticancer treatments.
  • To identify specific chemotherapeutic agents, targeted therapies, and radiotherapy linked to PAD and stroke.
  • To emphasize the importance of cardiovascular risk stratification and management in cancer patients.

Main Methods:

  • Literature review of studies on vascular complications of cancer therapies.
  • Identification of drugs and treatments associated with increased risk of PAD and stroke.
  • Analysis of mechanisms underlying treatment-induced vasculopathy.

Main Results:

  • Vascular endothelial growth factor inhibitors (VEGFIs), cisplatin, 5-fluorouracil, anthracyclines, proteasome inhibitors, and immunomodulatory agents are linked to stroke risk.
  • Head-and-neck radiotherapy doubles the risk of cerebrovascular events.
  • BCR-ABL tyrosine kinase inhibitors (TKIs), particularly second- and third-generation agents, are associated with a higher risk of PAD development.

Conclusions:

  • Patient's baseline cardiovascular risk factors, genetic predisposition, and specific treatment regimens influence the development of vascular complications.
  • Accurate cardiovascular risk stratification is essential for patients undergoing high-risk anticancer treatments.
  • Tailored treatment strategies and diligent clinical follow-up, including vascular ultrasound, can mitigate the incidence of PAD and stroke.