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Prothrombotic state induced by COVID-19 infection as trigger for stroke in young patients: A dangerous association

Francesco Cavallieri1,2, Alessandro Marti1, Antonio Fasano1,2

  • 1Neurology Unit, Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Eneurologicalsci
|June 23, 2020
PubMed

Insights

COVID-19 infection can cause inflammation and blood clots, potentially leading to strokes even in young individuals. Physicians should consider stroke as an early sign of coronavirus disease 2019 (COVID-19).

Area of Science:

  • Neurology
  • Infectious Diseases
  • Cardiology

Background:

  • COVID-19 infection is associated with a pro-inflammatory and pro-thrombotic state.
  • Cerebrovascular complications have been reported in patients with COVID-19.

Purpose of the Study:

  • To highlight the potential for cerebrovascular involvement in COVID-19.
  • To emphasize that stroke can be an initial manifestation of COVID-19.

Main Methods:

  • Review of clinical data and relevant literature on COVID-19 and cerebrovascular events.
  • Analysis of patient cases presenting with stroke and subsequent COVID-19 diagnosis.

Main Results:

  • COVID-19 infection can induce a pro-inflammatory and pro-thrombotic state.
  • Cerebrovascular events, including stroke, can occur in COVID-19 patients, including younger demographics.
  • Stroke may present as the primary symptom of COVID-19 infection.

Conclusions:

  • Healthcare providers must recognize the risk of stroke in COVID-19 patients.
  • Cerebrovascular complications should be considered in the differential diagnosis of stroke, particularly during the pandemic.
  • Early recognition of stroke as a potential COVID-19 symptom is crucial for timely management.

Keywords:
COVID-19CoronavirusProthrombotic stateStrokeVertebrobasilar disease

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