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Moderate substrate stiffness induces vascular smooth muscle cell differentiation through cellular morphological and

Kazuaki Nagayama1, Kouhei Nishimiya1

  • 1Micro-Nano Biomechanics Laboratory, Department of Mechanical Systems Engineering, Ibaraki University, Nakanarusawa-cho, Hitachi, Japan.

Bio-Medical Materials and Engineering
|June 23, 2020
PubMed
Summary

Optimal substrate stiffness promotes vascular smooth muscle cell (VSMC) differentiation. Cell shape and polarization are key factors in this process, offering insights into vascular remodeling.

Keywords:
Cell biomechanicsatomic force microscopy (AFM)mechanobiologysmooth muscle cell differentiationsubstrate stiffness

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