Related Experiment Video
Updated: Dec 17, 2025
07:56
Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
Published on: May 5, 2023
651
COVID-19 and the endothelium.
F Jung1, A Krüger-Genge2, R P Franke3
1Institute of Biotechnology, Molecular Cell Biology, Brandenburg University of Technology Cottbus-Senftenberg, Germany.
Clinical Hemorheology and Microcirculation
|June 23, 2020
Summary
COVID-19 damages the endothelial system, causing organ dysfunction through microcirculatory impairments. This, with inflammation and complement activation, promotes blood clot formation in COVID-19 patients.
Area of Science:
- Cardiovascular Science
- Infectious Disease Research
- Pathophysiology
Background:
- Emerging evidence indicates COVID-19's impact extends beyond pulmonary tissues, significantly affecting the vascular endothelial system.
- Studies highlight COVID-19's role in causing microcirculatory dysfunction, leading to impaired function across multiple internal organs.
- The interplay between endothelial dysfunction, systemic inflammation, and complement activation is increasingly recognized in severe COVID-19.
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