Related Experiment Video

Updated: Dec 17, 2025

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
07:56

Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis

Published on: May 5, 2023

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COVID-19 and the endothelium

F Jung1, A Krüger-Genge2, R P Franke3

  • 1Institute of Biotechnology, Molecular Cell Biology, Brandenburg University of Technology Cottbus-Senftenberg, Germany.

Clinical Hemorheology and Microcirculation
|June 23, 2020
PubMed

Insights

COVID-19 damages the endothelial system, causing organ dysfunction through microcirculatory impairments. This, with inflammation and complement activation, promotes blood clot formation in COVID-19 patients.

Area of Science:

  • Cardiovascular Science
  • Infectious Disease Research
  • Pathophysiology

Background:

  • Emerging evidence indicates COVID-19's impact extends beyond pulmonary tissues, significantly affecting the vascular endothelial system.
  • Studies highlight COVID-19's role in causing microcirculatory dysfunction, leading to impaired function across multiple internal organs.
  • The interplay between endothelial dysfunction, systemic inflammation, and complement activation is increasingly recognized in severe COVID-19.

Keywords:
COVID-19endocytosisendothelial cell dysfunctionendotheliitis

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