Iron- and cobalt-catalyzed C(sp3)-H bond functionalization reactions and their application in organic synthesis
Yungen Liu1, Tingjie You, Hai-Xu Wang
1Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P. R. China. cmche@hku.hk.
Abstract:
Direct C-H bond functionalization catalyzed by non-precious transition metals is an attractive strategy in synthetic chemistry. Compared with the precious metals rhodium, palladium, ruthenium, and iridium commonly used in this field, catalysis based on non-precious metals, especially the earth-abundant ones, is appealing due to the increasing demand for environmentally benign and sustainable chemical processes. Herein, developments in iron- and cobalt-catalyzed C(sp3)-H bond functionalization reactions are described, with an emphasis on their applications in organic synthesis, i.e., the synthesis of natural products and pharmaceuticals and/or their modification.
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