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Electro-thermal therapy: Microsecond duration pulsed electric field tissue ablation with dynamic temperature control

Michael B Sano1, Ross A Petrella1, Jacob D Kaufman1

  • 1UNC/ NCSU Joint Department of Biomedical Engineering, Raleigh, NC, USA.

Computers in Biology and Medicine
|June 23, 2020
PubMed
Summary

Electro-thermal therapy (ETT) rapidly creates focal liver ablations using pulsed electric fields and precise temperature control. This innovative cancer treatment shows potential for treating hepatic tumors effectively.

Keywords:
Cancer therapyH-FIREIrreversible electroporationNK-IREThermal ablation

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Area of Science:

  • Oncology
  • Biomedical Engineering
  • Medical Physics

Background:

  • Cancer treatment modalities are continuously evolving to improve efficacy and patient outcomes.
  • Focal ablation techniques are crucial for localized tumor destruction.
  • Existing energy-based therapies have limitations in precision and control.

Purpose of the Study:

  • To evaluate the ablative potential and characteristics of electro-thermal therapy (ETT).
  • To investigate the use of pulsed electric fields combined with precise temperature control for ablation.
  • To establish lethal electric field thresholds for hepatic tissue ablation at specific temperatures.

Main Methods:

  • Utilized an ex vivo perfused liver model to test ETT.
  • Employed high voltage (5000 V), short duration (2 μs) bipolar electrical pulses.
  • Implemented dynamic temperature control algorithms and applicator arrays for ablation delivery.
  • Correlated ablation zones with electric field isocontours using a single applicator setup.

Main Results:

  • Achieved 4 cm ablation zones in under 27 minutes using a three-applicator array.
  • Maintained tissue-electrode interface temperatures at 80°C during ablation.
  • Determined lethal electric field thresholds of 708 V/cm (45°C) and 867 V/cm (60°C).

Conclusions:

  • Electro-thermal therapy (ETT) is a viable method for hepatic tumor treatment.
  • ETT ablation profiles are comparable to other energy-based techniques.
  • ETT offers clinicians robust control over treatment parameters and safety.