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Updated: Dec 17, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Self-Assembled Bioactive Colloidal Gels as Injectable Multiparticle Shedding Platforms.

Bruno Freitas¹, Pedro Lavrador¹, Rui J Almeida¹

¹Department of Chemistry, CICECO - Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal.

ACS Applied Materials & Interfaces

|June 23, 2020

Summary

This summary is machine-generated.

Researchers developed novel colloidal gels from nanoparticles and nanogels for drug delivery. These gels enable controlled release of multiple nanoparticles, showing anti-inflammatory effects and efficient cellular uptake for biomedical applications.

Keywords:

biomaterials bottom-up self-assembly colloidal gels dynamic network nanoparticles

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Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery Systems

Background:

Standard nanotherapeutics face rapid clearance issues.
Development of self-assembled colloidal gels with autonomous multiparticle release is challenging.
Need for versatile platforms for localized nanotherapeutic delivery.

Purpose of the Study:

To create multiparticle colloidal gels with autonomous release capabilities.
To evaluate the anti-inflammatory activity and cellular uptake of these gels.
To establish a versatile platform for focalized multiparticle delivery.

Main Methods:

Assembly of cationic poly(d,l-lactide-co-glycolide)-polyethylenimine (PLGA-PEI) nanoparticles and anionic zein-hyaluronan (HA) nanogels.
Characterization of colloidal gel stability, moldability, and injectability.
Encapsulation of quercetin flavonoids and assessment of anti-inflammatory effects in macrophages.
Evaluation of autonomous multiparticle shedding and cellular internalization.

Main Results:

Successfully generated stable, moldable, and injectable multiparticle colloidal gels.
Achieved high loading efficacy of quercetin flavonoids with significant anti-inflammatory activity.
Demonstrated autonomous multiparticle shedding and efficient macrophage uptake of released particles.

Conclusions:

The developed nanostructured gels serve as an implantable platform for focalized multiparticle delivery.
The self-assembled colloidal system exhibits autonomous multiparticle shedding.
Combinatorial nanostructured gels can be manufactured for diverse biomedical applications.