MLLT10 in benign and malignant hematopoiesis
Related Experiment Video
Updated: Dec 17, 2025

Pan-myeloid Differentiation of Human Cord Blood Derived CD34+ Hematopoietic Stem and Progenitor Cells
Published on: August 9, 2019
Jamie L Deutsch1, Jessica L Heath2
1Department of Pediatrics, University of Vermont, Burlington, VT.
Abstract:
Non-random chromosomal translocations involving the putative transcription factor Mixed Lineage Leukemia Translocated to 10 (MLLT10, also known as AF10) are commonly observed in both acute myeloid and lymphoid leukemias and are indicative of a poor prognosis. Despite the well-described actions of oncogenic MLLT10 fusion proteins, the role of wild-type MLLT10 in hematopoiesis is not well characterized. The protein structure and several interacting partners have been described and provide indications as to the potential functions of MLLT10. This review examines these aspects of MLLT10, contextualizing its function in benign and malignant hematopoiesis.
Related Concept Videos
Differentiation of Common Myeloid Progenitor Cells
Hematopoiesis
Lineage Commitment
Regulation of Hematopoietic Stem Cells
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Multipotency of Hematopoietic Stem Cells

