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Lactobacillus rhamnosus GG and HbA1c in middle age and older adults without type 2 diabetes mellitus: A preliminary
Victoria E Sanborn1, M Andrea Azcarate-Peril2, John Gunstad3
1Department of Psychological Sciences, Kent State University, USA.
Background And Aims:
Probiotic supplementation improves glycemic control in persons with diabetes and the current study examined whether these benefits extend to healthy individuals.
Methods:
The current study was a 90-day placebo-controlled, double-blind, randomized clinical trial of Lactobacillus rhamnosus GG in healthy middle-aged and older adults. Fasting blood glucose and HbA1c were quantified at baseline and follow up.
Results:
ANCOVA controlling for baseline values showed group differences in follow up HbA1c [F (1,90) = 8.44, p = 0.005]; HbA1c values increased in the placebo group, though remained stable in the probiotic group.
Conclusions:
If replicated, Lactobacillus rhamnosus GG may protect against changes in glycemic control.
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