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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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SPHN - The Swiss Aging Citizen Reference (SACR).

Ayoung Jeong1,2, Murielle Bochud3, Philippe Cattin2

  • 1Swiss Tropical and Public Health Institute.

Studies in Health Technology and Informatics
|June 24, 2020
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Summary

This study establishes the Swiss Aging Citizen Reference (SACR) cohort to investigate aging biology and biomarkers. It aims to predict chronic diseases and extend healthy life expectancy by analyzing DNA methylation and brain imaging in 1000 participants.

Keywords:
DNA methylationSPHNagingbrain imagingcitizen referencepersonalized health

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Area of Science:

  • Gerontology and Personalized Health Research
  • Biomarker Discovery and Validation
  • Neuroscience and Aging

Background:

  • Switzerland faces a significant increase in its elderly population, necessitating research into aging biology.
  • Personalized health research focuses on extending healthy life expectancy through understanding aging mechanisms.
  • Novel molecular and imaging biomarkers are crucial for predicting and screening chronic diseases in aging populations.

Purpose of the Study:

  • To establish the Swiss Aging Citizen Reference (SACR) cohort for testing clinical and public health utility of biomarkers.
  • To serve as a testbed for scalable, accessible, and interoperable data on aging.
  • To conduct a proof-of-concept study linking epigenetic aging acceleration with brain structure and function.

Main Methods:

  • Combining and analyzing data from 1000 participants from existing Swiss citizen cohorts.
  • Utilizing DNA methylation and Magnetic Resonance Imaging (MRI) brain imaging techniques.
  • Performing an agnostic search for structural and functional brain features associated with epigenetic aging acceleration.

Main Results:

  • The establishment of the Swiss Aging Citizen Reference (SACR) cohort.
  • Identification of potential associations between epigenetic aging acceleration and brain features.
  • Demonstration of the feasibility of using epigenetic age acceleration as an intermediate aging biomarker.

Conclusions:

  • The SACR cohort provides a valuable resource for aging research and biomarker validation.
  • Epigenetic age acceleration shows potential as a biomarker for understanding brain aging mechanisms.
  • This research contributes to extending healthy life expectancy through personalized health strategies.