The systemic production of cytotoxic lymphoid cells in corneal allograft reaction. 1. A quantitantitative study...

The purpose of the study was to determine whether the mechanism of corneal allograft rejection is systemic in nature. Utilizing a 51Cr release assay in which labelled donor and recipient corneal cells were used as targets, it was demonstrated that cytotoxic cells specific for antigens located in donor corneal cells were present in spleen and lymph nodes.