Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MicroRNAs01:22

MicroRNAs

3.6K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.6K
MicroRNAs01:22

MicroRNAs

23.7K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.7K
Fractures: Bone Repair01:27

Fractures: Bone Repair

4.6K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Importance of Biochemical Screenings in the Diagnosis of Hypophosphatasia: Applications, Methodologies, and Challenges.

International journal of molecular sciences·2026
Same author

Oxidative Stress, MicroRNAs, and Long Non-Coding RNAs in Osteoarthritis Pathogenesis: Cross-Talk and Molecular Mechanisms Involved.

International journal of molecular sciences·2025
Same author

Serums miR-24-3p and miR-1301-3p as Potential Biomarkers in MEN1 Syndrome.

International journal of molecular sciences·2025
Same author

Establishment and Molecular Characterization of a Human Stem Cell Line from a Primary Cell Culture Obtained from an Ectopic Calcified Lesion of a Tumoral Calcinosis Patient Carrying a Novel <i>GALNT3</i> Mutation.

Genes·2025
Same author

Antiproliferative Role of Natural and Semi-Synthetic Tocopherols on Colorectal Cancer Cells Overexpressing the Estrogen Receptor β.

International journal of molecular sciences·2025
Same author

The Presence of the Endocannabinoid System in an In Vitro Model of Gorham-Stout Disease and Its Possible Role in the Pathogenesis.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Dec 17, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

238

Circulating miRNAs: A New Opportunity in Bone Fragility.

Simone Donati1, Simone Ciuffi1, Gaia Palmini1

  • 1Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Study of Florence, Viale Pieraccini 6, 50139 Florence, Italy.

Biomolecules
|June 24, 2020
PubMed
Summary

MicroRNAs (miRNAs) show promise as biomarkers for osteoporosis and fracture risk. Circulating miRNAs may enable early diagnosis and treatment monitoring for this bone disease.

Keywords:
bone fragilitycirculating miRNAsfracture risknoninvasive biomarkersosteoporosispersonalized medicine

More Related Videos

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.8K
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

8.6K

Related Experiment Videos

Last Updated: Dec 17, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

238
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.8K
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
10:37

Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform

Published on: November 30, 2016

8.6K

Area of Science:

  • Biochemistry
  • Genetics
  • Molecular Biology

Background:

  • Osteoporosis is a leading cause of fractures, marked by low bone mass and tissue deterioration.
  • Current fracture risk assessment tools are insufficient, necessitating novel biomarkers.
  • Epigenetic factors, particularly microRNAs (miRNAs), are increasingly implicated in osteoporosis development.

Purpose of the Study:

  • To review circulating microRNAs (c-miRNAs) as potential biomarkers for osteoporosis.
  • To explore the role of c-miRNAs in early diagnosis, treatment monitoring, and fracture risk assessment.

Main Methods:

  • Literature review of studies identifying miRNAs associated with osteoporosis and fracture risk.
  • Analysis of research on the presence and significance of c-miRNAs in biological fluids.

Main Results:

  • Several miRNAs have been linked to osteoporosis development and fracture risk.
  • Circulating miRNAs have been detected in biological fluids, suggesting potential predictive signatures.
  • c-miRNAs may offer insights into disease progression and treatment efficacy.

Conclusions:

  • c-miRNAs represent promising biomarkers for osteoporosis, aiding in early detection and personalized medicine.
  • Further research into c-miRNA signatures could improve fracture risk assessment and patient management.