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Electro-oculography in bilateral optic neuropathy
Padmini Dahanayake1,2, Tharaka L Dassanayake3,4,5, Manoji Pathirage4,6
1Department of Physiology, Faculty of Medicine, University of Peradeniya, Peradeniya, 20400, Sri Lanka. padminid@pdn.ac.lk.
BMC Research Notes
|June 24, 2020
Summary
Bilateral optic neuropathy impairs retinal pigment epithelium function, indicated by reduced electro-oculography light peak:dark trough ratios in patients. This suggests RPE involvement in optic nerve conditions.
Area of Science:
- Ophthalmology
- Neuroscience
- Cell Biology
Background:
- The impact of bilateral optic neuropathy on retinal pigment epithelium (RPE) function remains under-explored.
- Optic neuropathy can affect various retinal layers, but RPE-specific functional changes are not well-documented.
Purpose of the Study:
- To investigate the effect of bilateral optic neuropathy on electro-oculography (EOG) parameters, specifically the light peak:dark trough ratio, light peak, and dark trough.
- To determine if RPE function is altered in individuals with bilateral optic neuropathy.
Main Methods:
- An observational, cross-sectional study involving 37 patients with bilateral optic neuropathy and 40 healthy controls.
- Electro-oculography (EOG), pattern electroretinography (PERG), and visual evoked potentials (VEPs) were performed on all participants.
Main Results:
- Patients with bilateral optic neuropathy exhibited significantly reduced light peak:dark trough ratios (median 1.50 vs. 1.80 in controls, p < 0.001).
- A higher median dark trough value was observed in the patient group compared to controls.
- These EOG alterations suggest potential dysfunction of the retinal pigment epithelium.
Conclusions:
- The findings indicate that retinal pigment epithelium function may be compromised in cases of bilateral optic neuropathy.
- Potential mechanisms include altered ion channel conductance, subretinal space changes, choroidal circulation issues, or secondary photoreceptor abnormalities.
