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Without Missing a Beat: Absence of Cilia Informs the Diagnosis of Histopathologically Challenging Spitzoid
Michael T Tetzlaff1, Maya Farah2
1Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Translational and Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Abstract:
The diagnosis of Spitzoid melanocytic lesions remains a formidable challenge in dermatopathology. Numerous ancillary tests have evolved to improve accurate classification of histopathologically ambiguous lesions. A study by Lang et al. (2020b) demonstrates loss of primary cilia in Spitzoid melanoma compared with Spitz nevi and positions ciliation index as an informative ancillary test for Spitzoid lesions.
