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Updated: Dec 17, 2025
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A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
Published on: April 13, 2011
65.5K
Islet cell transplantation in children
Appakalai N Balamurugan1, Deborah A Elder2, Maisam Abu-El-Haija3
1Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH.
Seminars in Pediatric Surgery
|June 24, 2020
Summary
Pediatric total pancreatectomy with islet autotransplantation (TPIAT) offers a potential solution for chronic pancreatitis. This overview covers TPIAT procedures, outcomes, and discusses islet cell allotransplantation for children.
Area of Science:
- Pediatric surgery
- Endocrinology
- Transplantation immunology
Background:
- Chronic pancreatitis in children is a debilitating condition.
- Total pancreatectomy is sometimes necessary, leading to exocrine and endocrine insufficiency.
- Islet autotransplantation aims to preserve endocrine function.
Purpose of the Study:
- To provide a comprehensive overview of islet cell transplantation in pediatric patients.
- To focus specifically on the procedure of total pancreatectomy with islet autotransplantation (TPIAT).
- To review the current understanding and potential future directions for islet cell transplantation in children.
Main Methods:
- Review of existing literature on pediatric chronic pancreatitis and TPIAT.
- Summary of the TPIAT procedure, including islet isolation and transplantation techniques.
- Analysis of reported short-term and long-term outcomes and complications.
Main Results:
- TPIAT involves removing the pancreas and re-infusing the patient's own islets.
- Potential complications include bleeding, infection, and graft failure.
- Long-term results show variable success in preserving insulin independence.
Conclusions:
- TPIAT is a complex but viable option for select pediatric patients with chronic pancreatitis.
- Further research is needed to optimize outcomes and explore islet cell allotransplantation for children.
