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Do rat auditory event related potentials exhibit human mismatch negativity attributes related to predictive coding?
Jaishree Jalewa1, Juanita Todd2, Patricia T Michie2
1School of Psychology, University of Newcastle, Callaghan, New South Wales, Australia.
Hearing Research
|June 24, 2020
Summary
Rodent mismatch responses (MMRs) show promise as a biomarker for psychiatric disorders like schizophrenia. Rat MMRs mimic human auditory MMN responses, supporting their use in preclinical research.
Area of Science:
- Neuroscience
- Psychiatry
- Biomarkers
Background:
- Rodent models are crucial for disease research but struggle to replicate human psychiatric symptoms like schizophrenia.
- Auditory mismatch responses (MMRs) are being explored as translatable biomarkers for psychiatric disorders.
Purpose of the Study:
- To evaluate rodent mismatch responses (MMRs) as a reliable analogue of human mismatch negativity (MMN).
- To investigate if stimulus manipulations that affect human MMN also modulate rat MMRs.
Main Methods:
- Utilized epidural electroencephalography and wireless telemetry in freely-moving rats.
- Manipulated stimulus pitch, probability, and jitter to assess MMR modulation.
Main Results:
- Rat MMRs exhibited human-like modulations.
- Larger MMRs were elicited by deviant stimuli with greater pitch change, lower probability, and stable onset asynchrony (no jitter).
Conclusions:
- Rat MMRs serve as a valid analogue of human MMN.
- These findings support the use of rat MMRs for validating preclinical models of psychiatric disorders using a translatable biomarker.
