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Rising Incidence of Glioblastoma Multiforme in a Well-Defined Population.
Neil Grech1, Theresia Dalli1, Sean Mizzi2
1Department of Internal Medicine, Mater Dei Hospital, Msida, MLT.
Cureus
|June 24, 2020
Summary
Glioblastoma multiforme (GBM) incidence is rising, with a significant increase observed in Malta. Younger age and maximum safe resection (MSR) improved survival, but median survival remains low, necessitating further research.
Area of Science:
- Neuro-oncology
- Epidemiology
- Cancer Research
Background:
- Glioblastoma multiforme (GBM) incidence is increasing globally.
- Potential contributing factors include aging populations and environmental exposures.
- Understanding local GBM epidemiology is crucial for public health insights.
Purpose of the Study:
- To conduct a 10-year epidemiological study of GBM in Malta.
- To determine the incidence and trends of GBM.
- To compare findings with international GBM standards.
Main Methods:
- Histological GBM diagnoses from 2008-2017 in Malta were identified.
- Poisson regression analyzed incidence variations.
- Cox regression assessed survival factors, including maximum safe resection (MSR).
Main Results:
- 100 GBM cases were diagnosed between 2008-2017.
- GBM incidence significantly rose from 0.73 to 4.49 per 100,000.
- Younger age and MSR were linked to improved survival; median survival was 10 months.
Conclusions:
- Malta shows an increasing trend in GBM incidence.
- Median survival for GBM remains critically low.
- Further research into GBM causes and treatments is urgently needed.
