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Role of Skin in Vitamin D Synthesis01:23

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Updated: Dec 17, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Practical Vitamin D Supplementation Using Machine Learning.

Tyler Fugere1, Zhongning Jim Chen1, Issam Makhoul1

  • 1Division of Hematology and Oncology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Journal of Bone Metabolism
|June 24, 2020
PubMed
Summary
This summary is machine-generated.

Higher weekly vitamin D doses effectively correct deficiency in breast cancer patients. An online calculator helps clinicians choose optimal vitamin D replacement regimens for timely sufficiency.

Keywords:
Breast neoplasmsOsteoporosisVitamin D

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Area of Science:

  • Oncology
  • Endocrinology
  • Nutritional Science

Background:

  • Breast cancer patients face elevated osteoporosis risk.
  • Adequate vitamin D is crucial for preventing osteoporosis.
  • Timely correction of vitamin D deficiency is vital before initiating bone-modifying agents.

Purpose of the Study:

  • To identify the most effective vitamin D replacement regimens for correcting deficiency.
  • To predict the efficacy of various vitamin D repletion strategies.

Main Methods:

  • Retrospective cohort study of 2,164 female breast cancer patients.
  • Comparison of commonly used vitamin D replacement regimens based on weekly level change.
  • Statistical adjustment for age, race, BMI, creatinine clearance, endocrine therapy, and initial vitamin D levels.

Main Results:

  • Higher weekly vitamin D doses demonstrated a more significant impact on correction rates than lower daily doses.
  • A generalized linear model developed an online calculator to predict time to vitamin D correction.
  • The calculator accounts for patient characteristics and different replacement regimens.

Conclusions:

  • Clinicians should utilize the developed online calculator to select vitamin D replacement regimens.
  • The calculator aids in ensuring patients achieve vitamin D sufficiency promptly.
  • Optimizing vitamin D levels is essential for managing osteoporosis risk in breast cancer patients.